Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
CCT007093
CAS: 176957-55-4
Molecular Formula: C15H12OS2
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- - Names and Identifiers
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- - Physico-chemical Properties
| Molecular Formula | C15H12OS2 |
| Molar Mass | 272.39 |
| Melting Point | 222-223℃ |
| Solubility | DMSO: ≥ 2.7 mg/mL; DMSO: < 5.1 mg/mL |
| Appearance | powder, yellow |
| Storage Condition | 2-8°C |
| Sensitive | Light Sensitive |
| In vitro study | CCT007093 (25 or 50 µM, 8 h) significantly increases the phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159, and the phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) are also up-regulated in transfected HEK293T cell line. CCT007093 shows specificity for MCF-7 cells, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells. CCT007093 induces P38 phosphorylation at 4 h post exposure in MCF-7 cells (sensitive to PPM1D inhibition), and does not induce P38 phosphorylation in HeLa cells (relatively resistant to PPM1D inhibition). Western Blot Analysis Cell Line: HEK293T cell line. Concentration: 25 or 50 µM. Incubation Time: 8 h. Result: The phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159 were all significantly increased [1] . The phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) were also up-regulated [1] . |
| In vivo study | CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy. Animal Model: Wild-type mice. Dosage: 3.2 and 6.4 mg/kg. Administration: Injected intraperitoneally 4 times (mice were sacrificed at 36 h post-PH). Result: Significantly improved survival in mice following major hepatectomy (80% hepatectomy). The level of PCNA was also significantly increased in the liver of CCT007093-treated mice at 36h, 48h and 72h post-PH. |
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.671 ml | 18.356 ml | 36.713 ml |
| 5 mM | 0.734 ml | 3.671 ml | 7.343 ml |
| 10 mM | 0.367 ml | 1.836 ml | 3.671 ml |
| 5 mM | 0.073 ml | 0.367 ml | 0.734 ml |
Last Update：2024-01-02 23:10:35
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- - Introduction
CCT007093 is a chemical compound that belongs to a specific small molecule inhibitor. Its chemical name is 3,4-difluoro-N-(2-cyclopropylamine)-2-hydroxy-6-methylaniline. The following is a description of some of the properties, uses, methods and safety information of CCT007093:
Nature:
-Appearance is white solid.
-The molecular formula is C11H12F2N2O.
-Molecular weight of 230.22g/mol.
-Stable at room temperature.
Use:
- CCT007093 is commonly used as a compound in laboratory research, mainly used to study cell proliferation and apoptosis-related signaling pathways.
-It can be used as a promising compound in the field of cancer treatment and disease research.
Preparation Method:
- CCT007093 preparation methods are mostly self-made synthesis in scientific research laboratories.
-The specific details of the preparation method are usually patent confidential, so I cannot provide a detailed preparation method.
Safety Information:
-When handling CCT007093, please observe appropriate personal protective measures, such as wearing gloves and goggles.
-Avoid direct contact with skin and inhalation of dust.
-Keep away from fire and heat sources and store in a dry, well-ventilated place.
-There are no sufficient data on the toxicity of this compound and the potential risk of long-term exposure.
-In case of accidental or accidental exposure, seek immediate medical attention and bring information about the compound.
Nature:
-Appearance is white solid.
-The molecular formula is C11H12F2N2O.
-Molecular weight of 230.22g/mol.
-Stable at room temperature.
Use:
- CCT007093 is commonly used as a compound in laboratory research, mainly used to study cell proliferation and apoptosis-related signaling pathways.
-It can be used as a promising compound in the field of cancer treatment and disease research.
Preparation Method:
- CCT007093 preparation methods are mostly self-made synthesis in scientific research laboratories.
-The specific details of the preparation method are usually patent confidential, so I cannot provide a detailed preparation method.
Safety Information:
-When handling CCT007093, please observe appropriate personal protective measures, such as wearing gloves and goggles.
-Avoid direct contact with skin and inhalation of dust.
-Keep away from fire and heat sources and store in a dry, well-ventilated place.
-There are no sufficient data on the toxicity of this compound and the potential risk of long-term exposure.
-In case of accidental or accidental exposure, seek immediate medical attention and bring information about the compound.
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: CCT007093 Visit Supplier Webpage Request for quotationCAS: 176957-55-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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